[methyl(s)-3[1-(1,1-dimethylethoxycarbonyl)-1-h-imidaral-4-yl]-2-[(1,1-dimethylethoxycarbonyl)amino]propionate] - Names and Identifiers
Name | N(ALPHA) N-(IM)-DI-BOC-L-HISTIDINE
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Synonyms | Boc-L-His(Boc)-OMe N(ALPHA) N-(IM)-DI-BOC-L-HISTIDINE Na,N-(im)-Di-BOC-L-histidinemethylester n(α), n-(im)-di-boc-l-histidine methyl ester tert-butyl 4-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methoxy-3-oxopropyl]-1H-imidazole-1-carboxylate [methyl(s)-3[1-(1,1-dimethylethoxycarbonyl)-1-h-imidaral-4-yl]-2-[(1,1-dimethylethoxycarbonyl)amino]propionate] [Methyl(S)-3[1-(1,1-dimethylethoxycarbonyl)-1-H-imidazol-4-yl]-2-[(1,1-dimethylethoxycarbonyl)amino]propionate]
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CAS | 17791-51-4
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InChI | InChI=1/C17H27N3O6/c1-16(2,3)25-14(22)19-12(13(21)24-7)8-11-9-20(10-18-11)15(23)26-17(4,5)6/h9-10,12H,8H2,1-7H3,(H,19,22)/t12-/m0/s1 |
[methyl(s)-3[1-(1,1-dimethylethoxycarbonyl)-1-h-imidaral-4-yl]-2-[(1,1-dimethylethoxycarbonyl)amino]propionate] - Physico-chemical Properties
Molecular Formula | C17H27N3O6
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Molar Mass | 369.41 |
Density | 1.17g/cm3 |
Melting Point | 113-116 °C (lit.) |
Storage Condition | 2-8°C |
Refractive Index | 1.516 |
Physical and Chemical Properties | Storage Conditions: Store at 0-5 ℃ WGK Germany:3 |
[methyl(s)-3[1-(1,1-dimethylethoxycarbonyl)-1-h-imidaral-4-yl]-2-[(1,1-dimethylethoxycarbonyl)amino]propionate] - Risk and Safety
Safety Description | S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
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WGK Germany | 3 |
[methyl(s)-3[1-(1,1-dimethylethoxycarbonyl)-1-h-imidaral-4-yl]-2-[(1,1-dimethylethoxycarbonyl)amino]propionate] - Introduction
The N(ALPHA) N-(IM)-DI-BOC-L-HISTIDINE, also known as 4-((S)-t-BOC-amino-2-carbomethoxy), is an organic compound. Its properties are as follows:
1. Appearance: Usually a white crystalline solid.
2. Molecular formula: C13H23NO5.
3. Molecular Weight: 281.33.
4. Solubility: Soluble in common organic solvents, such as ethanol, methanol and dimethylformamide.
N(ALPHA) N-(IM)-DI-BOC-L-HISTIDINE have the following uses:
1. As a protecting group in organic synthesis: because its structure contains a protecting group (tert-butoxycarbonyl), it can be used to protect the reactivity of the amino group to avoid other reactions to change it, thus, it plays a protective role in the subsequent reaction.
2. As a chiral reagent: Because of its chiral structure, it can be used as a chiral inducer for the synthesis of chiral molecules.
3. Used in polypeptide synthesis: In polypeptide synthesis, it can be used as N-α protecting group to protect amino reactivity.
In terms of preparation, N(ALPHA) N-(IM)-DI-BOC-L-HISTIDINE can be synthesized by the following steps:
1. First, 2-methyl methacrylate is reacted with (S)-tert-butylamino group to obtain (S)-tert-butylamino-2-carbomethylgroup.
2. Reaction of the (S)-tert-butylamino-2-carbomethylgroup with N-hydroxythiobutanamide yields the (S)-tert-butoxycarbonylamino-2-carbomethylgroup.
For safety information, the specific safety information of N(ALPHA) N-(IM)-DI-BOC-L-HISTIDINE needs to refer to its relevant MSDS (chemical substance safety technical information sheet). In general, it should be stored in a cool, dry, well-ventilated place, and avoid contact with fire, heat and oxidizing agents. During use, wear appropriate protective equipment such as gloves, goggles and lab clothes. At the same time, follow the relevant operating procedures and safety measures to ensure personal safety and laboratory safety.
Last Update:2024-04-10 22:29:15